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An extracellular site of activation for PregS on endogenous NMDARs in primary rat hippocampal and chick spinal cord neurons in culture, as well as receptors expressed in Xenopus oocytes, was demonstrated by Farb et al

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Moreover, the expanded polyQ of ATXN3 can differentially interact with UPS components and interfere with the degradation of its proteolytic substrates [67, 76, 77]

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